Oncocytology

 
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Original Article
 
Scoring system of fine needle aspiration cytology samples for the detection of non-high-grade ductal breast carcinoma
Ayumi Ryu1, Akemi Takenaka2, Shigenori Nagata3, Yasuhiko Tomita4
1Cytologist, Department of Cytology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan.
2Chief Cytologist, Department of Cytology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan.
3Staff, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan.
3Chief, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan.

Article ID: 100004OCYAR2013
doi:10.5348/ocy-2013-4-OA-1

Address correspondence to:
Tomita Yasuhiko
Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases
1-3-3 Nakamichi, Higashinari, Osaka
Osaka 537-8511
Japan
Phone: 81-6-6972-1181
Fax: 81-6-6981-8336
Email: yasuhiko-tomita@umin.ac.jp

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How to cite this article:
Ryu A, Takenaka A, Nagata S, Tomita Y. Scoring system of fine needle aspiration cytology samples for the detection of non-high-grade ductal breast carcinoma. Oncocytology Journal 2013;3:1–7.


Abstract
Introduction: Although fine needle aspiration cytology (FNAC) is usually performed for breast lesions that are difficult to diagnose clinically and radiologically, in cases of carcinoma definitive diagnosis by FNAC is difficult in cases lacking obvious nuclear atypia, that are non-high-grade ductal carcinoma (NHGDC).
Aims: We aimed to clarify cytopathological characteristics useful for differential diagnosis between NHGDC and benign breast lesions.
Methods: We enrolled 62 patients who were difficult to diagnose or who were suspected of malignancy by routine FNAC examination. The definitive histopathological diagnosis was breast cancer in 42 patients and others in 21. The slides were re-examined to classify under the following 12 categories: dissociation of cells, cell size, cell uniformity, prominent nucleoli, nuclear margins, chromatin pattern, overlapping pattern of cells, presence of necrosis, presence of mucin, appearance of myoepithelial cells, appearance of bipolar bare nuclei, and appearance of foam cells.
Results: Univariate analysis revealed that chromatin pattern, nuclear margins, irregular overlapping of cells, appearance of myoepithelial cells, and appearance of bipolar bare nuclei were statistically significant. Multivariate analysis revealed that irregular overlapping of cells and appearance of myoepithelial cells were independent factors that were useful for differential diagnosis. Combination of these factors proved to be a useful marker in the differential diagnosis of breast lesions.
Conclusions: Application of the scoring system to future cases of breast lesions might clarify the usefulness of the system.

Key Words: Fine needle aspiration cytology, Non-high-grade ductal carcinoma, Multivariate analysis, Scoring system

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Author Contributions:
Ayumi Ryu - Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article
Akemi Takenaka - Drafting the article, Critical revision of the article
Shigenori Nagata - Drafting the article, Critical revision of the article
Yasuhiko Tomita - Drafting the article, Critical revision of the article, Final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
None
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Ayumi Ryu et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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