Oncocytology

 
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Original Article
 
Role of quantitative nuclear cytomorphometric and NOR dots count in prediction of carcinogenic induced oral cellular proliferative activity
Hussain Gadelkarim Ahmed1, Wijdan Muzamil Ibrahim Diab1, Shadan Atif Abdulgafar1, Awdah M. Al-hazimi2
1Department of Histopathology and cytology, Faculty of Medical Laboratory Science, University of Khartoum, Sudan.
2College of Medicine, Hail University, KSA.

Article ID: 100001OCYHGA2011
doi:10.5348/ocyj-2011-1-OR-1

Address correspondence to:
Hussain Gadelkarim Ahmed
University of Khartoum
102, FMLS
Khartoum
Sudan
Email: hussaingad1972@yahoo.com

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How to cite this article:
Ahmed HG, Diab WMI, Abdulgafar SA, Al-Hazimi AM. Role of quantitative nuclear cytomorphometric and NOR dots count in prediction of carcinogenic induced oral cellular proliferative activity. Oncocytology 2011;1:1–6.


Abstract
Aims: To find a better way for predicting the cellular proliferative activity of apparently healthy oral epithelium exposed to certain carcinogens.
Methods: The nuclear area (NA) and nucleolar organizer regions (NORs) counts were compared with that of cytological atypia in 100 cases of epithelia exposed to toombak (carcinogen), 100 controls (non-exposed) and two cases of squamous cell carcinoma (SCC), as internal controls.
Results: Significant differences in AgNOR (p<0.001) mean count and NA mean values (P<0.001) were identified between cases and controls. Significant differences were also noted in AgNOR mean count and NA mean values between cases and two cases of SCC.
Conclusions: AgNOR mean count and NA are useful markers for prediction of cytologically non-evident proliferative activity of oral mucosa exposed to carcinogens.

Key Words: Nuclear area, AgNOR, Oral epithelium

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Author Contributions:
Hussain Gadelkarim Ahmed - Substantial contributions to conception and design, acquisition of data, drafting the article, revising it critically for important intellectual content, final approval of the version to be published
Wijdan Muzamil Ibrahim Diab - Substantial contributions to conception and design, acquisition of data, interpretation of data, revising it critically for important intellectual content, final approval of the version to be published
Shadan Atif Abdulgafar - Substantial contributions to conception and design, acquisition of data, interpretation of data, revising it critically for important intellectual content, final approval of the version to be published
Awdah M. Al-hazimi - Substantial contributions to conception and design, acquisition of data, drafting the article, revising it critically for important intellectual content, final approval of the version to be published
Guarantor of submission:
The corresponding author is the guarantor of submission.
Source of support:
Nil
Conflict of interest:
Authors declare no conflict of interest.
Copyright:
© Hussain Gadelkarim Ahmed et al. 2011; This article is distributed the terms of Creative Commons attribution 3.0 License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.)



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